The narcotic antagonist, naloxone hydrochloride, may very well be administered when substantial respiratory melancholy happens with promethazine and codeine; any depressant results of promethazine aren't reversed with naloxone. Diazepam might be made use of to manage convulsions. Prevent analeptics, which may induce convulsions. Acidosis and electrolyte losses needs to be corrected. An increase in temperature or pulmonary complications may possibly sign the necessity for institution of antibiotic therapy.

Making use of this medicine with any of the subsequent medicines will not be advisable. Your doctor may determine not to deal with you with this medication or modify some of the other medicines you are taking.

Get health care enable without delay in the event you discover any of the following: sluggish/shallow respiratory, intense drowsiness/trouble waking up, confusion.

Right before having this medication, convey to your health care provider or pharmacist When you are allergic to any of its elements; or to opioid ache relievers (including morphine); or When you have any other allergy symptoms.

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There is no typical settlement about particular pharmacological cure regimens for uncomplicated NMS.

Promethazine and codeine use is contraindicated in pediatric individuals youthful than six many years. Concomitant utilization of promethazine products with other respiratory depressants has an Affiliation with respiratory melancholy, and in some cases death, in pediatric sufferers. Postmarketing scenarios of respiratory despair, including fatalities, have already been noted with an array of body weight-dependent promethazine doses in pediatric people younger than 2 a long time.

Procedure of overdosage is pushed by the general medical presentation, and consists of discontinuation of Promethazine with Codeine Oral Option alongside one another with institution of ideal therapy. Give Principal interest to your reestablishment of sufficient respiratory Trade as a result of provision of a patent and guarded airway and the institution of assisted or managed air flow.

Promethazine is contraindicated in comatose states, and in folks regarded website to be hypersensitive or to get had an idiosyncratic response to promethazine or to other phenothiazines.

- Symptoms of neuroleptic malignant syndrome; two or maybe more happen alongside one another; These types of effects will not need crisis healthcare notice when they manifest on your own

Young children are at bigger risk for significant (even deadly) Negative effects, In particular respiratory problems. Speak with the medical professional with regard to the risks and benefits of this medication.Cough-and-cold products don't remedy colds. Cough on account of a typical cold typically will not have to be taken care of with medication. Request your medical professional or pharmacist about other strategies To alleviate cough and cold indicators, for example consuming adequate fluids, using a humidifier, or saline nose drops/spray.

Constrained information advise that use of promethazine hydrochloride all through labor and shipping doesn't have an appreciable effect on the period of labor or delivery and isn't going to enhance the threat of have to have for intervention within the newborn.

The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and somewhat soluble in Alcoholic beverages.

Indicators and symptoms of overdosage with promethazine HCl vary from mild despair in the central anxious program and cardiovascular system to profound hypotension, respiratory melancholy, unconsciousness, and unexpected death.